|(1S,3aR,4S,6aR)-1-(3,4-二甲氧基苯基)-4-(3,4,5-三甲氧基苯基)六氢呋喃并[3,4-c]呋喃|CsnPharm

CAS No.: 31008-18-1

木兰苷 Catalog No. CSN11353

Synonyms: Magnolin

Magnolin, a natural product isolated and purified from the flowers of Magnolia biondii Pamp., reduces the renal oxidative stress, suppresses caspase-3 activity, and increases Bcl-2 expression in vivo and in vitro.

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生物活性

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技术信息

生物活性

描述Magnolin, a major component of Magnolia flos (Shin-Yi), inhibits the Ras/ERKs/RSK2 signaling axis by targeting the active pocket of ERK1 and ERK2 with IC50s of 87 nM and 16.5 nM, respectively. Magnolin inhibits cell migration and invasion by targeting the ERKs/RSK2 signaling pathway^[3]. Magnolin inhibited IgE/Ag-induced calcium mobilization, degranulation, and cytokines release in LAD2 cells. Magnolin attenuated IgE/Ag-induced mice paw swelling in a dose-dependent manner^[4]. Furthermore, magnolin-induced autophagy and cell cycle arrest suppress the growth of xenograft colorectal tumors without apparent toxicity. Magnolin induces autophagy and cell cycle arrest through LIF/Stat3/Mcl-1 pathway in CRCs (colorectal cancer)^[5]. Magnolin inhibited the proliferation and viability of the tumor cells by triggering cell cycle arrest via P53/P21 activation and inducing apoptosis in vitro and in vivo. Magnolin downregulated the phosphorylation of Akt protein kinase and upregulated cleaved Caspase3 during anti-proliferation and pro-apoptosis^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.4012 mL
- 12.0058 mL
- 24.0117 mL
- 5 mM
- 0.4802 mL
- 2.4012 mL
- 4.8023 mL
- 10 mM
- 0.2401 mL
- 1.2006 mL
- 2.4012 mL

技术信息

CAS号

31008-18-1

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C23H28O7

运输

蓝冰

分子量

416.46

别名

Magnolin

溶解度

DMSO	83.0 mg/mL (199.3 mM)

动物实验配方

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